Quantitative Determination of Paracetamol in Pharmaceutical Formulations by FTIR Spectroscopy
نویسنده
چکیده
The aim of this work was to use a spectrophotometric method for the determination of paracetamol in pharmaceutical formulations.The quantification of paracetamol through infrared spectroscopy was developed and validated for pharmaceuticals in tablet forms. The method involves the extraction of the active ingredient with chloroform and the measurement of the area of the infrared band corresponding to the carbonyl group centered at 1650cm. The specificity, linearity,detection limits,precision and accuracy of the calibration curve, paracetamol extraction, infrared analysis and data manipulation were determined in order to validate the method. The statistical results were compared with the quantification of paracetamol through UVdetection.The recovery values obtained in the analysis of pharmaceuticals are within the range 98-105%.
منابع مشابه
A New Sensor Based on Graphite Screen Printed Electrode Modified With Cu-Nanocomplex for Determination of Paracetamol
Paracetamol is a non-steroidal anti-inflammatory drug used as an antipyretic agent for the alternative to aspirin. Conversely, the overdoses of paracetamol can cause hepatic toxicity and kidney damage. Hence, the determination of paracetamol receives much more attention in biological samples and also in pharmaceutical formulations. Here, we report a rapid<span id="transmark" style="display: non...
متن کاملSimultaneous Quantification of Ibuprofen and Paracetamol in Tablet Formulations Using Transmission Fourier Transform Infrared Spectroscopy
A very simple, non-destructive, inexpensive and green strategy was applied for the simultaneous determination of ibuprofen (IBP) and paracetamol (PC) using transmission Fourier Transform Infrared (FTIR) spectroscopy in tablet formulations for routine quality control laboratories. For the determination of the active pharmaceutical ingredients (API), KBr pellets containing known amount of standar...
متن کاملLeast-squares support vector machine and its application in the simultaneous quantitative spectrophotometric determination of pharmaceutical ternary mixture
This paper proposes the least-squares support vector machine (LS-SVM) as an intelligent method applied on absorption spectra for the simultaneous determination of paracetamol (PCT), caffeine (CAF) and ibuprofen (IB) in Novafen. The signal to noise ratio (S/N) increased. Also, In the LS - SVM model, Kernel parameter (σ2) and capacity factor (C) were optimized. Excellent prediction was shown usin...
متن کاملSimultaneous determination of paracetamol, 4-Aminophenol, 4-Chloroacetanilid, Benzyl alcohol,Benzaldehyde and EDTA by HPLC methodin paracetamol injection ampoule
Paracetamol that is known as acetaminophen have the most consume as an analgesic and antipyreticdrug in the world. That is formulated in single compound or mixture at many forms such astablets, syrups, suspensions and drops. The last form is intravenous injections. Paracetamol derivedfrom 4-minophenol which is synthesized by acylated the P-acetaminophenol and acetic anhydride.4-aminophenol is t...
متن کاملStudy of Formulation of Mild Pharmaceutical Forms of Paracetamol in Medical Practice
INTRODUCTION Paracetamol is one of the most used antipyretic- analgesic preparation, which can be found in different pharmaceutical forms and in different doses. Due to its wide utilization in the clinical practice, determination of paracetamol in pharmaceutical formulation is of a great importance since that over dosage with paracetamol may cause the hepatic fulminant necroses and other toxic ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2010